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    <ns4:addinfo>&lt;a href='https://brc.riken.jp/mus/pcr00438'&gt;Genotyping protocol -PCR-&lt;/a&gt;</ns4:addinfo>
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    <dc:description xml:lang="ja">sek1(-/-)は胎生10〜12.5日で致死となる。継代はsek1(+/-)のへテロで行う。へテロマウスに異常は観察されていない。</dc:description>
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    <ns1:colonyMaintenance xml:lang="en">Backross to C57BL/6 (Heterozygote x C57BL/6J) Homozygous mutant mice die between embryonic day 10.5 and 12.5.</ns1:colonyMaintenance>
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    <ns4:termsAndConditions xml:lang="ja">条件を付加する。利用者は事前に寄託者の提供承諾書を得る。&lt;br&gt;研究成果の公表にあたって寄託者の指定する文献を引用する。&lt;br&gt;研究成果の公表にあたって謝辞の表明を必要とする。&lt;br&gt;公表を前提とした学術研究に限る。&lt;br&gt;分譲にあたっては寄託後、寄託者との共同研究とする。&lt;br&gt;利用者が当該リソースを使用した研究成果に基づく特許等の申請を行う場合は、寄託者と別途協議を行う。</ns4:termsAndConditions>
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    <dc:description xml:lang="en">B6.129P-Map2k4&lt;tm1Pngr&gt;.  The stress signaling kinase SEK1/MKK4 is a direct activator of stress-activated protein kinase, or Jun N-terminal kinases (SAPKs/JNKs) in response to environmental stress or mitogenic factors.  Homozygous mutant mice exhibit severe anemia and die between embryonic day 10.5 and 12.5.  This mutant strain is useful for the study of SEK1 gene function.</dc:description>
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    <ns1:strainDevelopment xml:lang="ja">1997年、仁科博史先生、トロント大学・オンタリオ癌研究所</ns1:strainDevelopment>
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    <dc:description xml:lang="ja">sek1(-/-)は胎生10〜12.5日で致死となる。,継代はsek1(+/-)のへテロで行う。へテロマウスに異常は観察されていない。</dc:description>
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    <ns1:colonyMaintenance xml:lang="ja">交配は、sek1(+/-)♂、C57BL/6♀で行って下さい。タイピングの必要有り。</ns1:colonyMaintenance>
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    <ns4:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Approval form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_6.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_d.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: MTA for distribution with RIKEN BRC (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;&lt;A HREF="https://www.tmd.ac.jp/mri/dbio/index.html" target="_blank"&gt;Lab HP (Japanese)&lt;/A&gt;</ns4:addinfo>
    <ns1:strainDevelopment xml:lang="en">Developed by Dr. Hiroshi Nishina at Ontario Cancer Institute, University of Toronto in 1997.  A neomycin selection cassette was inserted into the exon 2 of the SEK1 gene.  The SEK1 deficient mice were backcrossed to C57BL/6 over 13 times.</ns1:strainDevelopment>
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    <ns4:application>Cell Biology Research</ns4:application>
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    <ns1:donorDNA>mouse mitogen activated protein kinase kinase 4 genomic DNA, E. coli neo</ns1:donorDNA>
    <ns1:colonyMaintenance xml:lang="en">Backross to C57BL/6 (Heterozygote x C57BL/6J)Homozygous mutant mice die between embryonic day 10.5 and 12.5.</ns1:colonyMaintenance>
    <ns4:termsAndConditions xml:lang="en">The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers.&lt;br&gt;The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.&lt;br&gt;The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.</ns4:termsAndConditions>
    <ns6:brs_depositorOrganization xml:lang="en">Univ. Tokyo</ns6:brs_depositorOrganization>
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    <ns6:brs_depositor xml:lang="ja">仁科　博史</ns6:brs_depositor>
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    <dcterms:identifier>RBRC00438</dcterms:identifier>
    <skos:altLabel xml:lang="en">SEK1 Knockout mice</skos:altLabel>
    <skos:altLabel xml:lang="ja">SEK1 Knockout mice</skos:altLabel>
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    <dcterms:references rdf:resource="http://rdf.ncbi.nlm.nih.gov/pubmed/21664343"/>
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